- Before Frasier, Peri guest starred in an episode of Cheers as journalist Holly Matheson.
- Peri was the only one of the main cast five never nominated for an Emmy
- She appeared on the other creator/producer's shows: Cheers as a reporter and a bad date on Wings. Co-star Kelsey Grammer also appeared on all three programs
- Her father, Jim O'Brien, who was an anchor/reporter/weatherman at ABC O&O station WPVI-TV in Philadelphia passed away from a skydiving accident on September 25, 1983.