To celebrate Frasier's third anniversary as a radio talk show host, Roz gives him a cassette recording of his first broadcast. Listening to the tape makes Frasier reflect on how different his life was when he first moved back to Seattle. Flashback sequences highlight Frasier's raw on-air style and the very different nature of his relationships with his father, Martin, before Martin moved in with him, and even with his brother, Niles. Meanwhile, in present day, Daphne tries to decide whether to spend her vacation time back home with her family in England or on a sunny beach in Acapulco.
- Kelsey Grammer as Frasier Crane
- Jane Leeves as Daphne Moon
- David Hyde Pierce as Niles Crane
- Peri Gilpin as Roz Doyle
- and John Mahoney as Martin Crane
- John Rajeski as Writer
- Sherry Lansing as Angela
- The very first episode of The Dr. Frasier Crane Show was 21 May 1993, which was one day after the finale of Cheers aired on NBC
- Frasier's original producer, Dave, dropped Frasier. Roz tries to get transferred to a gardening show after their first call
- Frasier lived in Boston for 15 years.
- This episode indicates that when Frasier first returned to Seattle, he retained much of his old Boston self - proudly drinking plain black coffee (and scoffing at Niles' coffee order) and having a beer with his father (he typically drank beer at Cheers). At some point between his return and first episode of season one (three months later), Frasier's personality changes considerably.
- It is revealed that Martin came up with Frasier's signature catchphrase "I'm listening."
- The title comes from the posthumous novel "You Can't Go Home Again" by Thomas Wolfe, published in 1940.
- Despite being a flashback episode, the main characters' appearances are unchanged from the present (such as Frasier's short hair cut, Martin's completely grayed hair, etc.).